(Overview) AstraZeneca: Regulatory Strategy & Usability Design for a Leading Pathology Platform

The Business Problem & What I Learned:

With an industry-leading cancer research platform, the Oncology Data Science Platforms (ODSP) group was interested in a smoother research workflow for greater efficiency. After rapid research surfaced additional opportunities for commercial applications, my work was extended to solve for those challenges.

User Pain Points & Business Impacts:


  • Slow Onboarding & High Support Costs
    While technically impressive, the research software lacked any consideration for usability, forcing users to memorize workflows by rote, frequently request in-depth support, and generally slowed research workflows.

  • Infrequent, Problematic Edge Cases
    rained on limited patient data (HIPAA-anonymized), the system would occasionally return misleading results, increasing stress on pathologists’ peer review process and introducing the chance of serious mistakes.

  • Limited Applicability & Results
    Initial AI training had yielded a valuable research tool, but there was frustration amongst users that this functionality couldn’t be significantly expanded without a clear AI training strategy, limiting the yield on costly research.

Project Context & Design Strategy:

Initially tasked to provide a simple usability review, my research surfaced additional opportunities that I included in my presentation to product stakeholders:

Identified Issues:


  1. Shifting Regulatory Environments
    The team was exploring a potential commercial context (CDS/SaMD) for a “research use only” (RUO) tool.

  2. Problematic AI Results
    The QCS AI system could return infrequently ambiguous results that manual peer review needed to catch.

  3. HIPAA-Compliant Data Scope
    To improve the scanning of whole-slide images (WSI), a wider pipeline of data was needed without violating patient privacy.

  4. Lack of Usability reduced Research Efficiency
    Catering to functionality first, users took longer to onboard and frequently needed support.

What began as a scoped usability review surfaced a larger regulatory and commercial opportunity, prompting an extended engagement to help the team think through what this platform could become, not just how to fix its interface.


What We Delivered & The Impact:

Starting with an initial 2 week engagement focusing on usability, the project grew (8 weeks) to include foundational regulatory strategy and AI reliability work that:

Outcome #1: Positioned CPP for Regulated Commercial Release (CDS/SaMD)


By introducing FDA-aligned design documentation practices and a regulatory-compliant design strategy framework, the product team was equipped to:

  • Assess product opportunities across Clinical Decision Support (CDS) and Software as a Medical Device (SaMD) pathways.
  • Chart a design strategy aligned to International Medical Device Regulators Forum (IMDRF) CDS/SaMD risk categorization, groundwork for Predetermined Change Control Plan (PCCP) submission (i.e. AI/ML component), and related effort/cost estimates for executive review.

Outcome #2: Strengthened AI Result Reliability for Clinical-Grade Use


Working with SMEs to redesign the model's dataset scope and system feedback loop, the AI system was improved to:

  • Increase results accuracy from 94% to 99%+ on the validated test set (using “escape hatch” system feature), ensuring clinical accuracy and rapid peer-review for ambiguous results.
  • Establish a "human-in-the-loop" interaction pattern, surfacing AI-generated results as edited/reviewable design inputs, consistent with IEC 62366-1 use-error design principles.

Outcome #3: Expanded Diagnostic Insight via HIPAA-Compliant Data Scope


Through evaluation of the HIPAA Safe Harbor de-identification method, the team was able to:

  • Expand the training dataset (i.e. age, region, & gender) providing more detailed results and insight, without exposing Protected Health Information (PHI).

Outcome #4: Streamlined Pathologist Workflows


By applying a usability-driven redesign with standardized interaction patterns, the team achieved:

  • 20% increase in research task efficiency, with 70% reduction in support requests.
  • 40% reduction in new-user onboarding and training time.